Antibiotics in late clinical development by Prabhavathi Fernandes, Evan Martens PDF free download

Topics: BACTERIOSTATIC AGENTS, BACTERICIDAL AGENTS, Penicillin Binding Proteins, Penicillin, PENICILLINS ACTIVE BACTERIA, BETA LACTAMASE INHIBITORS, CEPHALOSPORINS, IMIPENEM, FOSFOMYCIN, VANCOMYCIN, METHICILLIN RESISTANCE, POLYMYXINS, Macrolides, Erythromycin, Azithromycin, Clarithromycin, CHLORAMPHENICOL, STREPTOGRAMINS, AMINOGLYCOSIDES, MITOCHONDRIAL PROTEIN SYNTHESIS, FOLIC ACID BIOSYNTHESIS, FLUOROQUINOLONE

Topics: Organ Systems, Cells, Organelles, Microbiota, Organ Systems, Water, Acids, Bases, Buffers, H+ Concentration, Disorders of Protein Misfolding, Protein Structure, Precursor Proteins, active protein, Proteolysis, Protease Inhibitors, Protein Folding, Autophagy, Protein Misfolding, Fibrillogenic Diseases, Chemical Kinetics, Thermodynamics, Enzymes, Enzyme RegulationActive Site, Enzyme–Substrate Complex, Michaelis–Menten Model, Enzyme-Catalyzed Reactions, Irreversible Inhibition, Inhibition, Clinical Enzymology, Biomarkers of Tissue Injury, Tissue Injury, Serum, Plasma Markers, Tissue Damage, Simple Carbohydrates, Simple Carbohydrates, Heteropolysaccharides, Glycoconjugates, Glycoproteins, Glycolipids, Cell Membrane Constituents, Cell-Surface Glycoproteins, Serum Glycoproteins, Connective Tissue, Fibrous Protein, Nonfibrous Protein, Proteoglycan, Gastrointestinal Digestion, Gastrointestinal Absorption, Gastrointestinal Tract, Gastrointestinal Hormones, Carbohydrate Metabolism, Glycolysis, Tricarboxylic Acid Cycle, Glycolysis, Pyruvate Metabolism, Tricarboxylic Acid Cycle, Electron Transport Chain, Oxidative Phosphorylation, Oxygen-Consuming Systems, Mitochondrial Structure, Mitochondrial Genome, Respiratory Chain Expression, Mitochondrial Diseases, Gluconeogenesis, Glycogen Synthesis, glycogen Breakdown, Alternative Pathways, Hexose Interconversion, Amino Acid Metabolism, Metabolism of Ammonia, Lipid, fatty acid, Eicosanoid, Fatty Acid Oxidation, Unsaturated Fatty Acid, Trans-Fatty Acid, Essential Fatty Acid, Phospholipids, Glycosphingolipids, Cholesterol, Phosphatidylcholine, Phosphosphingolipid, Catabolism, Storage Disorders of Sphingolipids, Sphingolipids, Acetyl-Coa, Hmg-Coa, Plasma Lipoprotein, Contractile Systems, Muscle Systems, Nonmuscle Systems, Energy Metabolism, Obesity, Diabetes Mellitus, Chromosomes, Chromatin, DNA, Recombinant DNA Technology, DNA Replication, DNA Repair, DNA Mutation, Protein Synthesis, RNA, Messenger RNA, Prokaryotic Transcription, Genetic Code, tRNA Molecule, Ribosomes, Gene Expression, mRNA Synthesis, Gene Regulation, Nucleotide Metabolism

Topics: Pharmacodynamics, Pharmacokinetics, Drug Metabolism, Pharmacogenomics, AUTONOMIC DRUGS, Autonomic Pharmacology, Cholinoceptor-Activating Drugs, Cholinesterase-Inhibiting Drugs, Cholinoceptor Blockers & Cholinesterase Regenerators, Sympathomimetics, Adrenoceptor Blockers, CARDIOVASCULAR DRUGS, Hypertension, Heart Failure, Antiarrhythmic Drugs, Diuretics, Histamine, Serotonin, Ergot Alkaloids, Vasoactive Peptides, Prostaglandins, Eicosanoids, Nitric Oxide, Asthma, Chronic Obstructive Pulmonary Disease, CNS Pharmacology, Sedative-Hypnotic Drugs, alcohol, Antiseizure Drugs, General Anesthetics, Local Anesthetics, Skeletal Muscle Relaxants, Parkinsonism, Movement Disorders, Antipsychotic Agents, Lithium, Antidepressants, Opioid Analgesics, Opioid Antagonists, Cytopenias, Hematopoietic Growth Factors, Coagulation Disorder, Dyslipidemia, NSAIDs, Acetaminophen, Rheumatoid Arthritis, Gout, ENDOCRINE DRUGS, Hypothalamic Hormones, Pituitary Hormones, Thyroid Drugs, Antithyroid Drugs, Adrenocorticosteroids, Adrenocortical Antagonists, Gonadal Hormones, Pancreatic Hormones, Antidiabetic Drugs, Glucagon, Bone Mineral Homeostasis, CHEMOTHERAPEUTIC DRUGS, Beta-Lactam Antibiotics, Cell Wall Antibiotics, Membrane-Active Antibiotics, Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, Oxazolidinones.Aminoglycosides, Spectinomycin, Sulfonamides, Trimethoprim, Fluoroquinolones, Antimycobacterial Drugs, Antifungal Agents, Antiviral Agents, Antimicrobial Agents, Disinfectants, Antiseptics, Sterilants, Antiprotozoal Drugs, Antihelminthic Drugs, Cancer Chemotherapy, Immunopharmacology, TOXICOLOGY, Environmental Toxicology, Occupational Toxicology, heavy metals, Poisoned Patient, Gastrointestinal Disorders, Dietary Supplements, Herbal Medications

Topics: Long-chain fatty acid, unsaturated fatty acid, odd-chain-length fatty acid, medium-chain-length fatty acid, very-long-chain-length fatty acid, long-chain branched-chain fatty acid

Topics: tetracycline, aminoglycosides, macrolides, clindamycin, chloramphenicol, Quinupristin-dalfopristin, streptogramins, Oxazolidinones, Linezolid

Topics: Biochemistry, Water, Buffers, Acid-Base Chemistry, carbohydrates, Polysaccharides, lipids, fatty acids, amino acids, Peptides, proteins, collagen, elastin, glycoproteins, plasma proteins, Immunoglobulins, enzymes, enzyme catalysis, Enzyme Kinetics, enzyme activity, Isoenzymes, cell structure, Biological Membranes, metabolism, bioenergetics, Tricarboxylic Acid Cycle, Glycolysis, Gluconeogenesis, Glycogen Metabolism, Pentose Phosphate Pathway, Uronic Acid Pathway, Lipid Metabolism, Adipose Tissue Metabolism, Lipoproteins, Fatty Liver Syndrome, Atherosclerosis, Prostaglandins, Amino Acid Metabolism, Protein Metabolism, nitrogen metabolism, Electron Transport Chain, Oxidative Phosphorylation, Mitochondrial Membrane Transporters, Mitochondrial Myopathies, Diabetes Mellitus, Porphyrin, Bile Pigments, haem, Jaundice, Haemoglobin, Myoglobin, Haemoglobinopathies, anaemias, vitamins, Water-soluble Vitamins, Fat-soluble Vitamins, minerals, Mineral Deficiency, Nucleic Acid Chemistry, Nucleotide Metabolism, Purine Metabolism, nucleotides, Pyrimidine Metabolism, Molecular Biology, DNA Structure, Genetic Role, Genetic Replication, Genetic Recombination, genetic code, protein targeting, Prokaryotic Gene Expression, Molecular Genetics, genetic diseases, Eukaryotic Chromosome, Gene Expression, DNA Amplification, DNA Cloning, Blotting Techniques, Nucleotide Probes, DNA Library, Recombinant DNA Technology, Genetic Engineering, Restriction Fragment Length Polymorphism, Polymerase Chain Reaction, Gastrointestinal Pathobiochemistry, digestion, absorption, organ function test, liver function test, Free Radical Scavenger Systems, free radicals, energy metabolism, energy nutrition, calorific values, balanced diet, Biochemical Endocrinology, Hormone Receptors, neurotransmitters, hormones, Hypothalamus-pituitary System, Hypothalamic Hormones, Gastrointestinal Hormones, androgens, oestrogens, progesterone, Calcium, phosphorus, cancer, Oncoproteins, immunology, Tumor Markers, Antigens, Immunogens, immune system, immune responses, Immunoglobulins, Immunological Techniques, Immunologic Dysfunction, thyroid function tests, adrenal function tests, renal function tests

Topics: Eukaryotic cell, cell, Carbohydrates, Monosaccharides, glucose, Disaccharides, Polysaccharides, Homopolysaccharides, Heteropolysaccharides, Agar, pectin, Glycoproteins, Lipids, Fatty acids, Essential fatty acids.Phospholipids, Glycolipids, Lipoproteins, Steroids, Amphipathic lipids, Soaps, detergents, Proteins, Amino Acids, Nucleic Acids, Nucleotides, Enzymes, DNA, RNA, enzyme activity, Active site, Enzyme inhibition, Enzyme specificity, Coenzymes, enzyme action, Non-protein enzymes, Isoenzymes, Vitamins, Vitamin A, Vitamin D, Vitamin E, Vitamin K, Vitamin C, Ascorbic acid, Thiamine, Vitamin B1, Riboflavin, Vitamin B2, Niacin, Pyridoxine, Vitamin B6, Biotin, Pantothenic acid, Folic acid, Cobalamin, Vitamin B12, Choline, Inositol, Lipoic acid, Para aminobenzoic acid, Bioflavonoids, Antivitamins, Physiological Biochemistry, Digestion, Absorption, Plasma Proteins, Albumin, Globulins, Immunoglobulins, Blood clotting, Hemoglobin, Porphyrins, Hemoglobin derivatives, Abnormal hemoglobins, Sickle-cell anemia, sickle-cell hemoglobin, Thalassemias, Porphyrias, Jaundice, Biological Oxidation, Bioenergetics, High-energy compounds, Electron transport chain, Oxidative phosphorylation, Metabolism, Glycolysis, Citric acid cycle, Gluconeogenesis, Glycogen metabolism, Glycogen storage diseases, Hexose monophosphate shunt, Uronic acid pathway, Glyoxylate cycle, Fatty acid oxidation, Ketone bodies, Fatty liver, obesity, Atherosclerosis, Alcohol metabolism, Amino acid pool, Urea cycle, Glycine, Phenylalanine, tyrosine, Tryptophan, Sulfur amino acids, One-carbon metabolism, Histidine, proline, arginine, Lysine, Glutamate, glutamine, Aspartate, asparagine, Serine, Threonine, Biogenic amines, Polyamines, purine, Mineral Metabolism, Nutrition, Hormones, Organ Function Tests, water, Tissue Proteins, Body Fluids, Molecular Biology, Biotechnology, DNA-Replication, Transcription, Translation, Gene Expression, Recombinant DNA, Human Genome Project, Gene Therapy, Bioinformatics, Xenobiotics, Detoxification, Prostaglandins, Free Radicals, Antioxidants, Environmental Biochemistry, Insulin, cancer, Acquired Immunodeficiency Syndrome

Topics: DEOXYRIBONUCLEIC ACID, DNA, Histone, B-DNA, A-DNA, Z-DNA, DNA DENATURATION, ANNEALING, DNA replication, Conservative Replication, Semi Conservative replication, Theta Replication, DNA POLYMERASE, Konberg Enzyme, DNA Helicase, DNA Premase, Nick Sealing Enzyme, Topoisomerase, DNA ligase, Single strand binding Protein, NUCLEIC ACID, PROKARYOTIC DNA POLYMERASE, EUKARYOTIC DNA POLYMERASE, REPLICATION FORK, RANSCRIPTION, genetic code, INITIATION COMPLEX

Topics: Protein Composition, Protein Structure, Amino Acids, Protein Three-Dimensional Structure, Protein Biochemistry, Enzyme Action, enzyme kinetics, enzyme regulation, Hemoglobin, Allosteric Protein, Carbohydrates, Lipids, Cell Membranes, Channels, Pumps, Receptors, Membrane Structure, Membrane Function, Signal-Transduction Pathways, digestion, metabolism, Glycolysis, Gluconeogenesis, Citric Acid Cycle, Oxidative Phosphorylation, Proton-Motive Force, Light Reactions, Calvin Cycle, Glycogen Degradation, Glycogen Synthesis, Pentose Phosphate Pathway, Glycogen Metabolism, Fatty Acid, Lipid Metabolism, Fatty Acid Degradation, Fatty Acid Synthesis, Lipid Synthesis, Storage Lipids, Phospholipids, Cholesterol, Amino Acid Degradation, Urea Cycle, Nucleic Acid Structure, DNA Replication, Amino Acid Synthesis, Nucleotide Metabolism, Informational Macromolecules, DNA, RNA, DNA Repair, DNA Recombination, RNA Synthesis, Gene Expression, RNA Processing, Protein Synthesis, Recombinant DNA Techniques, Genetic Code

Topics: Biochemistry, Organic Chemistry, functional groups, polymeric compounds, isomerism, amino acids, peptides, proteins, Enzymes, Biocatalysis, Chemical Equilibria, Chemical Energetics, catalysts, enzymes, energetic coupling, energy-rich compounds, enzyme catalysis, Michaelis theory, Coenzymes, prosthetic groups, Oxidoreductases coenzymes, Group-Transferring Coenzymes, nucleic acids, protein biosynthesis, bases nucleosides, nucleotides, deoxyribonucleic Acid, DNA biosynthesis, RNA synthesis, protein biosynthesis, virus biochemistry, Nucleic Acid-Cleaving Enzymes, Phosphatases, protein metabolism, proteolytic enzymes, Endopeptidases, Exopeptidases, Dipeptidases, Amino Acids, Decarboxylation, transamination, Oxidative Deamination, urea cycle, Porphyrins, Hemins, Porphyrin Catalysis blood pigment degradation, Cytochromes, Catalases, Peroxidases, Chlorophyll, biologic Oxidation, oxygen metabolism, Combustion, Biologic Oxidation, redox potential respiratory chain, Electron-Transport Particles, Oxidative Phosphorylation, Respiratory Chain Phosphorylation, Oxygen-Activating Enzymes, citrate cycle, Glyoxylate Cycle, fat metabolism, fats, fatty acids, Phosphatides, Cerebrosides, Gangliosides, Glycerophosphatides, Sphingolipids, cholesterol biosynthesis, sterols, plant steroids, vitamin D, bile acids, stroid hormones, carotenoids, Vitamin A, Tocopherol, Phylloquinone, Ubiquinone, Plastoquinone, Simple Sugars, Monosaccharides, Glucose Oxidation, Glycolysis, Alcoholic Fermentation, fructose metabolism, Aerobic Carbohydrate Breakdown, photosynthesis, Photophosphorylation, water photolysis, Glycosides, Oligosaccharides, Polysaccharides, glycoside bond, disaccharides, Polysaccharides, Homoglycans, Mucopolysaccharides, Carbohydrates Metabolism, fatty acids metabolism, protein metabolism, Endoplasmic Reticulum, cell, Mitochondria, cytoplasm, hormones, hormonal regulation, Adrenocortical Hormones, Gonadal Hormones, Thyroid Hormones, Parathyroid Hormone, Pancreatic Hormones, Hypophyseal Hormones, Tissue Hormones, Pheromones, mineral metabolism, water balance, active transport, Acid-Base Equilibrium, nutrition, vitamins, caloric value, Essential Food Components, Fat-Soluble Vitamins, Water-Soluble Vitamins, digestive tract, liver, blood kidney, urine, Excretion Products, Muscle biochemistry, Nerve Conduction biochemistry

Topics: Antibiotic, Antimicrobial, Drug antimicrobial activity, ANTIMETABOLITES, CELL WALL SYNTHESIS INHIBITORS, Penicillin, Cephalosporin, PROTEIN SYNTHESIS INHIBITORS, Aminoglycosides, Tetracyclines, chloramphenicol, macrolides, lincomycin, Nucleic acid synthesis inhibitors, Mycolic acid synthesis inhibitor, Cytoplasmic membrane inhibitors, ANTIMICROBIAL DRUG RESISTANCE, Transposon mediated resistance

Topics: PEPTIDOGLYCAN, Periplasm, BACITRACIN, MOA BACITRACIN, FOSFOMYCIN, MOA FOSFOMYCIN, CYCLOSERINE, MOA CYCLOSERINE, VANCOMYCIN, TEICOPLANIN, DAPTOMYCIN, POLYMIXIN

Topics: Oxazolidinones, Streptogramin, Spectinomycins, Mupirocin, Fosfomycin, Linezolid, Radezolid, Torezolid, posizolid, Streptogramins, Quinupristin, Dalfopristin

Topics: Transcobalamin, Vitamin B12 Deficiency, Pernicious Anaemia, FOLATE METABOLISM, Folate Absorption, Folate Transport, Macrocytosis

Topics: water, amino acids, peptides, proteins, protein function, enzymes, carbohydrates, glycobiology, nucleotides, nucleic acids, lipids, biological membrane, transport, biosignaling, catalysis, bioenergetics, biochemistry reaction types, glycolysis, metabolic regulation, citric acid cycle, fatty acid catabolism, amino acid oxidation, urea, metabolism, carbohydrate biosynthesis, lipid biosynthesis, hormonal regulation, information pathways, genes, chromosomes, DNA metabloism, RNA metabolism, Protein metabolism, regulation of gene expression

Topics: Autonomic Pharmacology, autonomic drugs, Cholinoceptor-Activating Drug, Cholinesterase-Inhibiting Drug, Cholinoceptor-Blocking Drugs, Adrenoceptor Agonists Drug, Sympathomimetic Drug, Adrenoceptor Antagonist Drug, cardiovascular-renal drug, Antihypertensive Agents, Vasodilators, Treatment of Angina Pectoris, Heart Failure, Cardiac Arrhythmias, Diuretic Agents, actionson smooth muscle, central nervous system, inflammation, gout, endocrine drugs, chemotherapeutic drugs, toxicology, Heavy Metal Intoxication, Chelators, Poisoned Patient, Beta-Lactam, Cell Wall Antibiotics, Membrane-Active Antibiotics, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, Oxazolidinones, Aminoglycosides, Spectinomycin, Sulfonamides, Trimethoprim, Quinolones, Antimycobacterial Drugs, Antifungal Agents, antiviral agents, Antimicrobial Agents, Disinfectants, Antiseptics, Sterilants, Antimicrobial Agents, Antiprotozoal Drugs, Antihelminthic Drugs, Cancer Chemotherapy, Immunopharmacology, Hypothalamic Hormones, Pituitary Hormones, Thyroid drugs

Topics: Medical Biochemistry, amino acids, proteins, carbohydrates, lipids, membranes, transport, oxygen transport, catalytic proteins, enzymes, vitamins, minerals, bioenergetics, oxidative metabolism, anaerobic metabolism, Tricarboxylic Acid Cycle, tricarboxylic acid biosynthesis, oxidative metabolism, carbohydrate biosynthesis, fatty acid biosynthesis, amino acids biosynthesis, nucleotides, complex carbohydrates, complex lipids, extracellular matrix, Deoxyribonucleic Acid, ribonucleic acid, protein synthesis, gene expression, genomics, proteomics, metabolomics, membrane receptors, signal transduction, neurotransmitters, biochemical endocrinology, cellular homeostasis, aging, digestion, absorption, glucose homeostasis, fuel metabolism, nutrients, diets, lipoprotein metabolism, Atherogenesis, water homeostasis, electrolyte homeostasis, muscle, bone metabolism, calcium homeostasis, neurochemistry, blood, plasma proteins, hemostasis, thrombosis, oxidative stress, inflammation, immune response

Topics: Prokaryotic DNA Polymerase, DNA Polymerase, Polymerase III Assembly, Polymerase III Holoenzyme and E. coli DNA, DNA Helicase and Gyrase Activity

Topics: COMBINATION THERAPY, LACTAMS, penicillins, cephalosporins, Antimicrobial Spectrum, Semisynthetic Penicillins, LACTAM ALLERGY, SULFONAMIDES, TRIMETHOPRIM-SULFAMETHOXAZOLE, QUINOLONES, URINARY TRACT ANTISEPTICS, sulfanilamide, para-aminobenzene sulfonamide, quinolone, CIPROFLOXACIN, OFLOXACIN, SPARFLOXACIN

Topics: nalidixic acid, Ciprofloxacin, Sparfloxacin, Fluoroquinolone, Trovafloxacin, Levofloxacin, Fluoroquinolone Drug Interactions