Topics: PLANT-DRUG DISCOVERY, Drug Discovery Process, Genomics, proteomics, Current therapy, Assay Development, Hit Validation, Lead Compound, Lead Optimisation, Preclinical Evaluation, Preclinical toxicity studies, In vivo tests, Test validity, Multiple Ascending Dose, drug Development

Topics: amoebiasis, antiamebic drugs, amebic colitis, MIXED ANTIAMEBIC DRUGS, Mixed amebicides, METRONIDAZOLE, LUMINAL ANTIEMEBIC DRUGS, DILOXANIDE FUROATE, IODOQUINOL, PAROMOMYCIN, Luminal amebicides, tissue amebicides, DEHYDROEMETINE, EMETINE, stystemic amebicides, CHLOROQUINE, TETRACYCLINES

Topics: ANTIBIOTIC RESISTANCE, INACTIVATION OF ENZYMES, DRUG BINDING, DRUG SENSITIVE SITE, MULTI DRUG RESISTANCE

Topics: Dose-Response Relationship, Pharmacokinetics, Pharmacodynamics, drug absoprtion, drug distribution, Drug Elimination, Pharmacokinetic Principles, Nervous System, Peripheral Efferent Nervous System, Parasympathomimetic Drugs, Anticbolinergic Drugs, Sympathomimetic Drugs, Adrenergic Receptor Antagonists, diuretics, Antidiuretic Drugs, Antihypertensive Drugs, Congestive Heart Failure, Antianginal Agents, Anti.anhythmic Drugs, Sedative-Hypnotic Drugs, Antipsychotic Drugs, Neuroleptic Drugs, Antidepressant Drugs, Anticonvulsants, Parkinson Disease, Alzheimer Disease, Antiepileptic Drugs, Anesthetics, Opioid Analgesics, Antagonists, AUTOCOIDS, ERGOTS, ANTI-INFLAMMATORY AGENTS, IMMUNOSUPPRESSIVE AGENTS, Histamine, Antihistamine, Serotonin Agonists, Serotonin Antagonists, Ergot Alkaloids, Eicosanoids, Salicylates and Nonsteroidal Anti-inflammatory Drugs, NSAIDs, Immunosuppressive Drugs, Hemostatic Disorder, anaemia, Antiemetics, obesity, Infectious Disease Therapy, Antibacterial Agents, Antimycobacterial Agents, Antifungal Agents, Antiparasitic Drugs, Antiviral Drugs, Antiretroviral Drugs, Cancer Chemotherapy, Alkylating Agents, Antimetabolites, Microtubule Damaging Agents, Topoisomerase Inhibitors, Antitumor Antibiotics, Antineoplastic Agents, Corticosteroids, Hormone Therapy, TOXICOLOGY, Insecticides, Herbicides, Heavy Metal Poisoning, solvents

Topics: Pharmacogenomics, Pharmacoepidemiology, DRUG SPECIFICITY, receptor classification, drug concentration, drug effect, spare receptors, COMPETITIVE ANTAGONISM, Irreversible Competitive Antagonism, Partial Agonists, Constitutive Receptor Activation, Inverse Agonists, two-state receptor model, Biased Agonism, Allosteric Modulation, Chemical Antagonism, Pharmacokinetic Antagonism, Receptor–Response Linkage, Physiological Antagonism, Desensitisation, Tolerance, Altered Drug Metabolism, Binding Reaction, Drug–Receptor Interactions, Receptor mechanisms, Ion Channels, Enzymes, Receptor Proteins, Receptor Heterogeneity, Ligand-Gated Ion Channels, Gating Mechanism, G Protein–Coupled Receptors, Proteinase-Activated Receptors, G proteins, phospholipase C, inositol phosphate system, Inositol phosphates, intracellular calcium, Diacylglycerol, protein kinase, MAP kinase system, GPCR desensitisation, Biopharmaceuticals, Chemical Mediators, Presynaptic Modulation, Postsynaptic Modulation, Cholinergic transmission, Nicotinic Receptors, Acetylcholine, Muscarinic Agonists, Muscarinic Antagonists, Ganglion Stimulants, Ganglion-Blocking Drugs, Neuromuscular-Blocking Drugs, Non-Depolarising Blocking Agents, Depolarising Blocking Agents, Cholinesterase Reactivation, Noradrenergic transmission, Adrenoceptor Agonists, α-Adrenoceptor antagonists, 5-Hydroxytryptamine, migraine, Adenosine, purine, Histamine, local hormone, Eicosanoids, Prostanoids, Leukotrienes, Platelet-Activating Factor, Bradykinin, peptide, Neuropeptides, Cytokine, Interferon, Cannabinoids, Endocannabinoids, Nitric oxide, Ischaemic Heart Disease, Antidysrhythmic Drugs, Myocardial Contraction, Anti-Anginal Drugs, Organic Nitrates, Calcium Antagonists, Endothelin, Vasoactive Drugs, Vasodilator Drugs, heart failure, Atherosclerosis, lipoprotein metabolism, Lipoprotein Transport, Lipid-Lowering Drugs, Fibrates, Haemostasis and thrombosis, Blood Coagulation, Warfarin, Platelet Adhesion, Platelet Activation, Antiplatelet Drugs, Adenosine Receptor Antagonists, Fibrinolysis, Thrombolysis, Fibrinolytic Drugs

Topics: drug disposition, TDM service protocols, Drug assay techniques, Gas-liquid chromatography, High-performance liquid chromatography, Radioimmunoassay, Cardioactive drugs, Bronchodilators

Topics: Pharmacotherapeutics, Pharmacokinetics, Pharmacogenomics, Pharmacological effect, Therapeutic index, Therapeutic Range, Steady state, pharmacokinetic studies, Therapeutic drug monitoring testing, Minimum Effective Concentration, Maximum Therapeutic Concentration, Minimum Toxic Concentration, Half Life of a drug, First order kinetics, Zero order kinetics, Michaelis-Menten kinetics, Kinetic homogeneity, Antiepileptics, Antimanics, Antineoplastics, Bronchodilators, Chromatographic techniques, Thin layer chromatography, High performance liquid chromatography, Gas chromatography–mass spectroscopy, Therapeutic Range, Antiarrythmics, Antibiotics, Immunosuppressives

Topics: drug action, Altered GIT absorption, Chelation, drug-induce mucosal damage, Passive tubular reabsorption, PHARMACODYNAMIC INTERACTION

Topics: Sedative-Hypnotic Drugs, benzodiazepines, gamma-aminobutyric acid, Benzodiazepine Binding Site Ligands, Antiseizure Drugs, Phenytoin, Carbamazepine, Seizure Disorders, Status epilepticus

Topics: Psychopharmacology, Drugs, brain, behavior, Nervous System, chemical signaling, Catecholamines, Neurotransmitter Synthesis, Neurotransmitter Receptors, Synaptic Plasticity, Catecholamine Synthesis, Dopaminergic System, Noradrenergic System, Serotonin, Serotonin Synthesis, Serotonergic System, Acetylcholine, Cholinergic System, Glutamate, drug abuse, drug addiction, alcohol, Alcohol Use Disorder, Opioids, Narcotic Analgesics, Opioid Receptors, Endogenous Neuropeptides, Psychomotor Stimulants, Cocaine, Amphetamine, Nicotine, Caffeine, cigarette smoking, vaping, Marijuana, Cannabinoids, Hallucinogens, Ketamine, Mescaline, Psilocybin, Inhalants, Anabolic–Androgenic Steroids, Anxiety Disorder, Affective Disorders, Antidepressants, Mood Stabilizers, Schizophrenia, Antipsychotic Drugs, Neurodegenerative Diseases, Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease, Amyotrophic Lateral Sclerosis, Multiple Sclerosis