Topics: Drug – receptor binding, GRADED DOSE RESPONSE CURVE, Agonist, antagonist, COMPETITIVE ANTAGONISM, IRREVERSIBLE ANTAGONISM, QUANTAL DOSE RESPONSE CURVE, Desensibilisation, tachyphylaxis, Tachyphylaxis

Topics: PLANT-DRUG DISCOVERY, Drug Discovery Process, Genomics, proteomics, Current therapy, Assay Development, Hit Validation, Lead Compound, Lead Optimisation, Preclinical Evaluation, Preclinical toxicity studies, In vivo tests, Test validity, Multiple Ascending Dose, drug Development